After general anesthesia, the rats were placed in a supine position with their legs naturally bent at the hips and knees
Microchim Acta 186 , 604 (2019)
According to some embodiments, the therapeutic amount of the Silybum marianum active ingredient is at least about 200 mg, at least about 195 mg, at least about 190 mg, at least about 185 mg, at least about 180 mg, at least about 175 mg, at least about 170 mg, at least about 165 mg, at least about 160 mg, at least about 155 mg, at least about 150 mg, at least about 145 mg, at least about 140 mg, at least about 135 mg, at least about 130 mg, at least about 125 mg, at least about 120 mg, at least about 115 mg, at least about 110 mg, at least about 105 mg, at least about 100 mg, at least about 95 mg, at least about 90 mg, at least about 85 mg, at least about 80 mg, at least about 75 mg, at least about 70 mg, at least about 65 mg, at least about 60 mg, at least about 55 mg, at least about 50 mg, at least about 45 mg, at least about 40 mg, at least about 35 mg, at least about 30 mg, at least about 25 mg, at least about 20 mg, at least about 15 mg, or at least about 10 mg, for daily administration
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